abstract：OBJECTIVE:To determine the relationship between treatment outcomes and hand-foot syndrome (HFS), and the relationship between survival rate and post-progression treatment after sorafenib therapy. METHODS:The study assessed 314 patients with advanced hepatocellular carcinoma (HCC) treated with sorafenib at 5 general ho...

journal_title：Oncology

authors： Ogawa C,Morita M,Omura A,Noda T,Kubo A,Matsunaka T,Tamaki H,Shibatoge M,Tsutsui A,Senoh T,Nagano T,Takaguchi K,Tani J,Morishita A,Yoneyama H,Masaki T,Moriya A,Ando M,Deguchi A,Kokudo Y,Minami Y,Ueshima K,Sakur

更新日期：2017-01-01 00:00:00

abstract：:Pancreatic intraepithelial neoplasia (PanIN) is a microscopic papillary noninvasive lesion arising from the pancreatic ductal epithelium. However, the natural history and time to progression of high-grade PanIN remain unclear. Herein, we report 2 cases of high-grade PanIN without morphological changes of the main panc...

journal_title：Oncology

authors： Yamao K,Takenaka M,Nakai A,Omoto S,Kamata K,Minaga K,Miyata T,Imai H,Sakurai T,Watanabe T,Nishida N,Matsumoto I,Takeyama Y,Chikugo T,Kudo M

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Oncogene-driven stress-related DNA damage has been observed in lesions of colon cancer. Furthermore, DNA sensors and nucleases are stimulated during active DNA damage and replication. However, their changes and influences with respect to cancer remain largely unknown. METHODS:The gene expression levels of cG...

journal_title：Oncology

authors： Yang CA,Huang HY,Chang YS,Lin CL,Lai IL,Chang JG

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:Choriocarcinoma is the most common epithelial cancer among gestational trophoblastic diseases (GTDs); the mechanism of trophoblastic carcinogenesis is unknown. This study aimed to examine the expression of NF-κB family proteins in GTDs and placental tissues as well as the roles of c-Rel in choriocarcinoma. M...

journal_title：Oncology

authors： Sekiya Y,Yamamoto E,Niimi K,Nishino K,Nakamura K,Kotani T,Kajiyama H,Shibata K,Kikkawa F

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the clinical and cost benefits of the administration of aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting (CINV) during high-dose chemotherapy (HDCT). METHODS:We retrospectively reviewed the charts of patients who received HDCT at our institution between January 2009 and ...

journal_title：Oncology

authors： Nakamura A,Kojima Y,Miyazawa K,Matsumoto S,Iida H,Nagai H

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:The present study sought to evaluate an inflammation-based prognostic score (Glasgow prognostic score, GPS) and the neutrophil to lymphocyte ratio (NLR) as prognostic factors in patients receiving chemotherapy for advanced gastric cancer. METHODS:The study enrolled 224 patients who received chemotherapy for...

journal_title：Oncology

authors： Namikawa T,Munekage E,Munekage M,Maeda H,Yatabe T,Kitagawa H,Kobayashi M,Hanazaki K

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:BRAF D594G mutations in colorectal cancer patients are not clearly understood. We retrospectively investigated the clinicopathological features of colorectal cancers with BRAF D594G mutations. METHODS:We selected 908 colorectal cancer patients who underwent surgical resection from January 2008 to January 201...

journal_title：Oncology

authors： Amaki-Takao M,Yamaguchi T,Natsume S,Iijima T,Wakaume R,Takahashi K,Matsumoto H,Miyaki M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Patients with localized gastric adenocarcinoma (LGAC), who get pre-operative therapy, have heterogeneous/unpredictable outcomes. Predictive clinical variables/biomarkers are not established. METHODS:We analyzed 107 LGAC patients who had chemoradiation and surgery. LGACs were grouped for (1) presence/absence...

journal_title：Oncology

authors： Charalampakis N,Nogueras González GM,Elimova E,Wadhwa R,Shiozaki H,Shimodaira Y,Blum MA,Rogers JE,Harada K,Matamoros A Jr,Sagebiel T,Das P,Minsky BD,Lee JH,Weston B,Bhutani MS,Estrella JS,Badgwell BD,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Ovarian cancer is the most lethal gynecological malignancy, but information relevant to prognosis and outcomes remain unknown. Here, we used statistical methods to focus specifically on interactions between candidate prognostic variables. METHODS AND RESULTS:Univariate, multivariate, and elastic net modeling...

journal_title：Oncology

authors： Jatoi A,Vierkant RA,Hawthorne KM,Block MS,Ramus SJ,Larson NB,Fridley BL,Goode EL

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:MicroRNA (miR)-503 is downregulated in several cancers and plays a tumor-suppressive role in carcinogenesis. However, the miR-503 expression pattern, its clinical significance and its molecular mechanism in colorectal cancer (CRC) have not been investigated. METHODS:We analyzed miR-503 expression in normal ...

journal_title：Oncology

authors： Noguchi T,Toiyama Y,Kitajima T,Imaoka H,Hiro J,Saigusa S,Tanaka K,Inoue Y,Mohri Y,Toden S,Kusunoki M

更新日期：2016-01-01 00:00:00

abstract：:Malignant gastrointestinal neuroectodermal tumor (GNET) is an aggressive rare tumor, primarily occurring in young adults with frequent local-regional metastases and recurrence after local control. The tumor is characterized by the presence of EWSR1-ATF1 or EWSR1-CREB1 and immunohistochemical positivity for S-100 prote...

journal_title：Oncology

authors： Subbiah V,Holmes O,Gowen K,Spritz D,Amini B,Wang WL,Schrock AB,Meric-Bernstam F,Zinner R,Piha-Paul S,Zarzour M,Elvin JA,Erlich RL,Stockman DL,Vergilio JA,Suh JH,Stephens PJ,Miller V,Ross JS,Ali SM

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:To investigate the role of adjuvant radiation therapy in locoregional control in patients with locoregionally advanced papillary thyroid carcinoma (pT4 or pN1b) based on a comparison of a group that received radiation therapy and a group that did not receive radiation therapy. METHODS:A retrospective analys...

journal_title：Oncology

authors： Lee NK,Kim CY,Baek SK,Jung KY

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:A novel oral agent that consists of trifluridine and tipiracil hydrochloride (TFTD) has been established as salvage-line treatment for metastatic colorectal cancer (mCRC). Adherence to TFTD is crucial to maintaining appropriate curative effects. This study sought to clarify adherence to TFTD and identify can...

journal_title：Oncology

authors： Sugita K,Kawakami K,Yokokawa T,Sugisaki T,Takiguchi T,Aoyama T,Suzuki K,Suenaga M,Yamaguchi K,Inoue A,Machida Y,Yamaguchi T,Hama T

更新日期：2016-01-01 00:00:00

abstract：PURPOSE:This phase I study (EudraCT No. 2006-001177-25) investigated aflibercept, a vascular endothelial growth factor decoy receptor protein (VEGF Trap), in combination with docetaxel, cisplatin, and 5-fluorouracil in patients with advanced solid tumors. PATIENTS AND METHODS:Patients received 2, 4, or 6 mg/kg of intr...

journal_title：Oncology

authors： Bahleda R,Baker J,Massard C,Gadgeel SM,Rogers JE,Izzedine H,Deutsch E,Garris JL,Khan A,Boelle E,Assadourian S,Soria JC,Ajani JA

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The impact of ethnicity and the socioeconomic status (SES) among Caucasians is not well studied. Here, we examine the impact of income on melanoma presentation and prognosis within a Caucasian cohort, accounting for ethnicity, as some reports suggest increased melanoma incidence in Ashkenazi Jewish (AJ) BRCA...

journal_title：Oncology

authors： Salvaggio C,Han SW,Martires K,Robinson E,Madankumar R,Gumaste P,Polsky D,Stein J,Berman R,Shapiro R,Zhong J,Osman I

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The prognosis of patients with locally advanced squamous cell carcinoma (SCC) of the tongue is poor. Postoperative chemoradiotherapy (CRT) improves locoregional control and survival in high-risk patients. We investigated the prognostic factors for clinical T4a tongue SCC, and elucidated whether postoperative ...

journal_title：Oncology

authors： Yokota T,Iida Y,Ogawa H,Kamijo T,Onozawa Y,Todaka A,Hamauchi S,Onoe T,Nakagawa M,Yurikusa T,Tanuma A,Yamashita A,Nishimura T,Yasui H,Onitsuka T

更新日期：2016-01-01 00:00:00

abstract：:Acute myeloid leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target in AML. Eradication of LSCs should be a critical and efficient therapeutic approach for the cure of AML. T-cell immunoglobulin mucin-3 (TIM-3) is expressed in most types of AML LSCs, but not in normal ...

journal_title：Oncology

authors： Kikushige Y,Miyamoto T

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Transarterial chemoembolization (TACE) is recommended as a first-line therapy for hepatocellular carcinoma (HCC) patients ineligible for curative therapy and without portal invasion. The Assessment for Retreatment with TACE (ART) scoring system was recently proposed for identifying patients who would not show...

journal_title：Oncology

authors： Arizumi T,Ueshima K,Iwanishi M,Minami T,Chishina H,Kono M,Takita M,Kitai S,Inoue T,Yada N,Hagiwara S,Ida H,Minami Y,Sakurai T,Nishida N,Kitano M,Kudo M

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:HER2 positivity is reported to be <20% in gastric cancer. Clinicopathological characteristics will be helpful to understand the biological features of HER2-positive gastric cancer. METHODS:A total of 813 gastric cancer patients who underwent HER2 testing between January 2005 and December 2010 were included ...

journal_title：Oncology

authors： Park JS,Rha SY,Chung HC,Jung M,Kim KH,Jun HJ,Kim H,An JY,Kim HI,Cheong JH,Hyung WJ,Noh SH,Kim HS

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To report the outcomes of surgical resection of borderline resectable (BL) and locally advanced (LA) 'unresectable' pancreatic cancer after neoadjuvant chemotherapy. METHODS:A review of a prospectively maintained database for pancreatic resections was undertaken to identify patients undergoing resection for ...

journal_title：Oncology

authors： Addeo P,Rosso E,Fuchshuber P,Oussoultzoglou E,De Blasi V,Simone G,Belletier C,Dufour P,Bachellier P

更新日期：2015-01-01 00:00:00

abstract：:Magnetic resonance imaging-guided laser interstitial thermal therapy (LITT) is a minimally invasive treatment modality with recent increasing use to ablate brain tumors. When originally introduced in the late 1980s, the inability to precisely monitor and control the thermal ablation limited the adoption of LITT in neu...

journal_title：Oncology

authors： Rahmathulla G,Recinos PF,Kamian K,Mohammadi AM,Ahluwalia MS,Barnett GH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Ovarian clear cell carcinoma (CCC) has a poorer prognosis than other subtypes of ovarian cancer. In this study, we evaluated the responsiveness to second-line chemotherapy in recurrent ovarian CCC. METHODS:The MITO-9 project investigated a cohort of patients observed between 1991 and 2007 in 20 cen...

journal_title：Oncology

authors： Esposito F,Cecere SC,Magazzino F,Katsaros D,Ottaiano A,Gadducci A,Pisano C,Scalone S,Rabaiotti E,Salutari V,Cormio G,Canuto EM,Greggi S,Savarese A,Marinaccio M,Scollo P,Santeufemia DA,Sacco C,Facchini G,Pignata S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Patients with localized esophageal and esophagogastric junction cancer (EAC) receive chemoradiation and then surgery (trimodality, TMT) or definitive chemoradiation (bimodality, BMT). Distant metastases (DMs) are common but the details of their distribution and timing in a large cohort have not been describe...

journal_title：Oncology

authors： Shiozaki H,Sudo K,Xiao L,Wadhwa R,Elimova E,Hofstetter WL,Skinner HD,Lee JH,Weston B,Bhutani MS,Blum MA,Maru DM,Ajani JA

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:We conducted this study to compare tumor measurement by computed tomography (CT) and tumor response assessment between Response Evaluation Criteria In Solid Tumors (RECIST) 1.0 and RECIST 1.1 in patients with metastatic colorectal cancer (CRC). METHODS:We reviewed the medical records of patients with metasta...

journal_title：Oncology

authors： Jang HJ,Kim BC,Kim HS,Kim JH,Song HH,Kim JB,Park JJ,Yoon SN,Woo JY,Zang DY

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:A novel delivery system for transdermal matrix patches of fentanyl has been developed. The new fentanyl tape consists of a backing layer, a drug-containing layer and a release liner that is originally made of rubber adhesive. This open-label prospective study investigated the pharmacokinetics and safety of t...

journal_title：Oncology

authors： Saito T,Fujii M,Saito S,Shimada K,Fujiwara K,Kobayashi K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Transforming growth factor beta (TGF-β) plays an important role in tumorigenesis and metastasis. It works as a tumor suppressor in the normal colon, but acts as a cancer promoter during the late stages of colorectal carcinogenesis. High expression of TGF-β is known to be associated with advanced stages, tumor...

journal_title：Oncology

authors： Chun HK,Jung KU,Choi YL,Hong HK,Kim SH,Yun SH,Kim HC,Lee WY,Cho YB

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:In most guidelines, no other interventional therapy but liver transplantation is recommended for the treatment of hepatocellular carcinoma (HCC) with Child-Pugh C cirrhosis (CP-C). However, in Japan, patients were sometimes treated with expectation of benefit. SUMMARY:A workshop was conducted to explore the...

journal_title：Oncology

authors： Nouso K,Kokudo N,Tanaka M,Kuromatsu R,Nishikawa H,Toyoda H,Oishi N,Kuwaki K,Kusanaga M,Sakaguchi T,Morise Z,Kitai S,Kudo M

更新日期：2014-01-01 00:00:00

abstract：:In the 2010 version of the Japan Society of Hepatology (JSH) consensus-based treatment algorithm for the management of hepatocellular carcinoma (HCC), transarterial chemoembolization (TACE) failure/refractoriness was defined assuming the use of superselective lipiodol TACE, which has been widely used worldwide and par...

journal_title：Oncology

authors： Kudo M,Matsui O,Izumi N,Kadoya M,Okusaka T,Miyayama S,Yamakado K,Tsuchiya K,Ueshima K,Hiraoka A,Ikeda M,Ogasawara S,Yamashita T,Minami T,Liver Cancer Study Group of Japan.

更新日期：2014-01-01 00:00:00

abstract：:The aim of this study was to both develop and validate a nomogram based on the Ki-67 index to predict recurrence. We constructed a nomogram using the Cox proportional hazards model with 953 N0 and N1 postoperative hormone receptor (HR)-positive breast cancer patients and validated it in an external cohort of 895 patie...

journal_title：Oncology

authors： Park YH,Im SA,Cho EY,Ahn JH,Woo SY,Kim S,Keam B,Lee JE,Han W,Nam SJ,Park IA,Noh DY,Yang JH,Ahn JS,Im YH

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Ethnic disparities in cancers are associated with variability in clinical outcomes. We present a Surveillance Epidemiology and End RESULTS (SEER)-based outcome analysis of multiethnic Waldenström's macroglobulinemia (WM) patients. METHODS:Adult WM patients diagnosed in 1992 or later (n = 3,175) were analyze...

journal_title：Oncology

authors： Ailawadhi S,Kardosh A,Yang D,Cozen W,Patel G,Alamgir MA,Chanan-Khan AA

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Our aim was to assess FDG-PET/CT as a surrogate biomarker of the pathological complete response in locally advanced rectal cancer treated with neoadjuvant chemoradiation. METHODS:T3-4 and/or N+ rectal cancer patients were treated prospectively with capecitabine-based chemoradiation and total mesorectal exci...

journal_title：Oncology

authors： Bampo C,Alessi A,Fantini S,Bertarelli G,de Braud F,Bombardieri E,Valvo F,Crippa F,Di Bartolomeo M,Mariani L,Milione M,Biondani P,Avuzzi B,Chiruzzi C,Pietrantonio F

更新日期：2013-01-01 00:00:00

abstract：:Until a few decades ago neck dissection (ND) was the standard surgical approach for node-positive tumours. Nowadays patients with locally advanced head and neck cancer can be treated with definitive chemoradiation (CRT), which includes the treatment of the neck; however, results on residual viable tumour after conserv...

journal_title：Oncology

authors： Denaro N,Russi EG,Numico G,Pazzaia T,Vitiello R,Merlano MC

更新日期：2013-01-01 00:00:00

abstract：PURPOSE:Patient nonadherence to oral antineoplastic therapy is a well-recognized barrier to effective treatment. In order to identify patients who may need additional support to become adherent, it is important to have a useful tool that takes into account all the parameters of adherence to prescription. The aim of thi...

journal_title：Oncology

authors： Thivat E,Van Praagh I,Belliere A,Mouret-Reynier MA,Kwiatkowski F,Durando X,Mahammedi H,Dillies AF,Chollet P,Chevrier R

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to assess the use of 5-fluorouracil (5-FU), leucovorin and oxaliplatin (FOLFOX) regimens in clinical practice according to their efficacy and toxicity. METHODS:Patients who received oxaliplatin-containing regimens after curative resection for colorectal carcinoma from 10 different o...

journal_title：Oncology

authors： Uncu D,Aksoy S,Çetin B,Yetişyiğit T,Özdemir N,Berk V,Dane F,Inal A,Harputluoğlu H,Budakoğlu B,Koca D,Sevinç A,Cihan S,Durnalı AG,Özkan M,Öztürk MA,Işıkdoğan A,Büyükberber S,Benekli M,Köş T,Alkış N,Karaca H,Tur

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...

journal_title：Oncology

authors： Oki E,Emi Y,Akagi Y,Tokunaga S,Sadanaga N,Tanaka T,Ogata Y,Saeki H,Kakeji Y,Baba H,Nishimaki T,Natsugoe S,Shirouzu K,Maehara Y,Kyushu Study Group of Clinical Cancer.

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:This open-label, randomized phase III trial evaluated larotaxel/cisplatin versus gemcitabine/cisplatin as first-line treatment for locally advanced (T4b) or metastatic urothelial tract or bladder cancer. METHODS:Patients were randomized to larotaxel 50 mg/m(2) with cisplatin 75 mg/m(2) every 3 weeks (larota...

journal_title：Oncology

authors： Sternberg CN,Skoneczna IA,Castellano D,Theodore C,Blais N,Voog E,Bellmunt J,Peters F,Le-Guennec S,Cerbone L,Risse ML,Machiels JP

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:It was the aim of this study to report on the role of laparoscopic staging in a large series of locally advanced cervical cancer (LACC) patients and its impact on prognosis. METHODS:Consecutive patients with LACC were considered for surgical staging: gynecological examination, cystoscopy and laparoscopy with...

journal_title：Oncology

authors： Benedetti Panici P,Perniola G,Tomao F,Fischetti M,Savone D,Di Donato V,Angioli R,Muzii L

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:The current study aimed to compare the therapeutic outcomes of surgery with those of chemoradiation for patients with advanced oropharyngeal cancer (OPC). METHODS:The data for 523 patients with previously untreated OPC were obtained from 12 institutions belonging to the Head and Neck Cancer Study Group in th...

journal_title：Oncology

authors： Kano S,Homma A,Hayashi R,Kawabata K,Yoshino K,Iwae S,Hasegawa Y,Nibu K,Kato T,Shiga K,Matsuura K,Monden N,Fujii M

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:Angiogenesis plays an important role in ovarian cancer. The interaction of platelet-derived growth factor receptor-beta (PDGFR-β) with vascular endothelial growth factor (VEGF) in the process of angiogenesis may represent an essential feature in the progression of the disease. METHODS:Patients with epitheli...

journal_title：Oncology

authors： Mathey S,Graeser MK,Zu Eulenburg C,Woelber L,Trillsch F,Jaenicke F,Müller V,Milde-Langosch K,Mahner S

更新日期：2013-01-01 00:00:00

abstract：:A large number of targeted anticancer drugs are currently under development and most of them will have a companion diagnostic linked to their use. If a diagnostic assay is developed in conjunction with a targeted anticancer drug, such an assay will later end up determining the conditions for the use of the drug after ...

journal_title：Oncology

authors： Jørgensen JT

更新日期：2013-01-01 00:00:00